This article aims to clarify the epistemological foundations of the Freudian energetics model, starting with a historical review of the 19th century scientific context in which Freud's research lay down its roots. Beyond the physiological and anatomical references of Project for a Scientific Psychology, the physiology Freud makes reference to is in reality primarily anchored in an epistemological model derived from physics. Whilst across the Rhine, the autonomy of physiology in relation to physics was far from being accomplished, as a (...) counterpoint, in France, the revolution in physiology driven by Claude Bernard established itself autonomously from physics,. In contrast, Freud's scientific landscape is entirely dominated by the physics elevated to the rank of an ideal science. The influence of Helmholtz, who is both a medical doctor and a physicist, has a determining influence on Freud's training. The discoveries in physics at that time, in particular the formulation of the principle of 'conservation of force' - first principle of thermodynamics - will constitute the points of reference upon which Freud will elaborate his energetics model, then subsequently, the idea of economy in his metapsychology. In this way we can trace both the historic and epistemological path that led Freud from a concept based on physics, and more specifically thermodynamic energy, to an idea of nervous energy that constitutes the basis of the concept of "quantity" as it is stated as 'first fundamental idea' in Project for a Scientific Psychology. This notion will subsequently evolve, and lead Freud to the introduction of the concept of 'psychical energy,' this time in a purely metapsychological sense. (shrink)

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Comment Sortir de la Terreur. by Bronislaw Baczko The Kiss of Lamourette. by Robert Darnton Les Origines Culturelles de la Revolution Francaise. by Roger Chartier Naissance du Journal Revolutionnaire. by Claude Labrosse; Pierre Retat "Mere Words," The Journal of Modern History, June 1991. by Dorinda Outram Revolutionary News: The Press in France 1789-1799. by Jeremy D. Popkin.

Ce livre est la première biographie consacrée à l'une des plus grandes figures intellectuelles et politiques du XXe siècle : Cornelius Castoriadis (1922-1997). Jeune résistant grec révolutionnaire menacé de mort par les staliniens, il arrive en France à l'âge de vingt-trois ans, alors que l'engouement pour l'URSS est à son zénith. Il contribue alors à créer, avec Claude Lefort et Jean-François Lyotard, l'une des branches les plus vivaces de la gauche radicale, « Socialisme ou Barbarie », qui deviendra ensuite (...) une revue mythique et l'une des grandes influences de Mai 68, notamment par sa critique de gauche des régimes dits « communistes ». Économiste, philosophe, psychanalyste, militant politique, Castoriadis est l'auteur d'une œuvre essentielle pour quiconque s'intéresse à la question de l'institution hors du cadre de l'État, dont il traite dans ce que l'on peut considérer comme l'un des maîtres ouvrages du XXe siècle, L'Institution imaginaire de la société (1975). Il n'a en effet cessé, en croisant l'analyse historienne et l'approche psychanalytique, de s'attacher à penser la conquête de l'autonomie comme condition de l'approfondissement démocratique. Fruit d'une enquête menée auprès d'une centaine de témoins, cet ouvrage permet enfin de lever le voile sur cette figure hors norme et trop méconnue, qui est restée marginale jusqu'au bout, malgré son élection comme directeur d'études à l'EHESS au début des années 1980. Celui en qui Pierre Vidal-Naquet voyait un « génie », et Edgar Morin un « Titan de l'esprit », est pourtant très certainement appelé, en ces temps de grandes turbulences des souverainetés établies, à devenir l'un des penseurs-clés du XXIe siècle. (shrink)

_Democracy Past and Future_ is the first English-language collection of Pierre Rosanvallon's most important essays on the historical origins, contemporary difficulties, and future prospects of democratic life. One of Europe's leading political thinkers, Rosanvallon proposes in these essays new readings of the history, aims, and possibilities of democratic theory and practice, and provides unique theoretical understandings of key moments in democracy's trajectory, from the French Revolution and the struggles for universal suffrage to European unification and the crises of the (...) present. In so doing, he lays out an influential new theory of how to write the history of politics. Rosanvallon's historical and philosophical approach examines the "pathologies" that have curtailed democracy's potential and challenges the antitotalitarian liberalism that has dominated recent political thought. All in all, he adroitly combines historical and theoretical analysis with an insistence on the need for a new form of democracy. Above all, he asks what democracy means when the people rule but are nowhere to be found. Throughout his career, Rosanvallon has resisted simple categorization. Rosanvallon was originally known as a primary theorist of the "second left", which hoped to stake out a non-Marxist progressive alternative to the irresistible appeal of revolutionary politics. In fact, Rosanvallon revived the theory of "civil society" even before its usage by East European dissidents made it globally popular as a non-statist politics of freedom and pluralism. His ideas have been shaped by a variety of influences, ranging from his work with an influential French union to his teachers François Furet and Claude Lefort. Well known throughout Europe as a historian, political theorist, social critic, and public intellectual, Pierre Rosanvallon was recently elected to a professorship at the Collège de France, Paris, a position held at various times by Claude Lévi-Strauss, Michel Foucault, and Pierre Bourdieu. _Democracy Past and Future_ begins with Rosanvallon's groundbreaking and synthetic lecture that he delivered upon joining this institution. Throughout the volume, Rosanvallon illuminates and invigorates contemporary political and democratic thought. (shrink)

« Toute activité se laisse discerner et définir dans la mesure où elle prend forme, où elle inscrit sa courbe dans l’espace et le temps. La vie agit essentiellement comme créatrice de formes. La vie est forme, et la forme est le mode de la vie » (Henri Focillon). Formes de la géométrie et du cosmos, formes de la vie et de la pensée, formes architecturales, musicales et littéraires, formes fixes ou métamorphoses : le concept de forme est omniprésent dans (...) les sciences et dans les arts. C’est à une exploration de cette notion de forme que le Collège de France a consacré en octobre 2011 son colloque multidisciplinaire de rentrée : sa définition en philosophie chez Platon et Aristote, ses applications en mathématiques et en astrophysique, en chimie et en biologie, ses conséquences en psychologie et en linguistique, en anthropologie, en droit et dans les arts. Ces débats ont été aussi l’occasion de se tourner vers des pensées où elle joue un rôle particulièrement important, comme le structuralisme de Claude Lévi-Strauss ou l’histoire de l’art d’André Chastel. Jean-Pierre Changeux est professeur honoraire au Collège de France, chaire de Communications cellulaires. Il a dirigé la publication de trois colloques précédents du Collège de France : La Vérité dans les sciences (2003), Gènes et culture (2003) et L’Homme artificiel(2007). Contributions de Antoine Compagnon, Claude Debru, Stanislas Dehaene, Mireille Delmas-Marty, Philippe Descola, Anne Fagot-Largeault, Marcel Hénaff, Michel Hochmann, Jean-Jacques Hublin, François-Bernard Mâche, Jean-François Mangin, Jean-Claude Pecker, Jacques Reisse, John Scheid, Jesper Svenbro. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Background The often poor prognosis associated with cancer necessitates empowering patients to express their care preferences. Yet, the prevalence of Advance Directives (AD) among oncology patients remains low. This study investigated oncologists' perspectives on the interests and challenges associated with implementing AD. Methods A French national online survey targeting hospital-based oncologists explored five areas: AD information, writing support, AD usage, personal perceptions of AD's importance, and respondent's profile. The primary outcome was to assess how frequently oncologists provide patients with information (...) about AD in daily clinical practice. Additionally, we examined factors related to delivering information on AD. Results Of the 410 oncologists (50%) who responded to the survey, 75% (n = 308) deemed AD relevant. While 36% (n = 149) regularly inform patients about AD, 25% (n = 102) remain skeptical about AD. Among the respondents who do not consistently discuss AD, the most common reason given is the belief that AD may induce anxiety (n = 211/353; 60%). Of all respondents, 90% (n = 367) believe patients require specific information to draft relevant AD. Physicians with experience in palliative care were more likely to discuss AD (43% vs 32.3%, p = 0.027). Previous experience in critical care was associated with higher levels of distrust towards AD (31.5% vs 18.8%, p = 0.003), and 68.5% (n = 281) of the respondents expressed that designating a “person of trust” would be more appropriate than utilizing AD. Conclusion Despite the perceived relevance of AD, only a third of oncologists regularly apprise their patients about them. Significant uncertainty persists about the safety and relevance of AD. (shrink)

In this paper, we engage with the widespread and influential approach of National Innovation Systems (NIS). We discuss its adequacy to non-OECD countries, especially in Latin America where it tends to be reified. Although the NIS approach is meant to address the most pressing needs of the economies it applies to, we argue that it would benefit from developing a more encompassing scope, allowing integration of greater diversity and complexity. By retracing the history of regimes of science, technology and innovation (...) in Latin America, we explore the following paradox: whereas numerous Southern scholars urge the pressing need to develop an innovation agenda for Southern countries with a “Southern framework of thought”, they continue to heavily rely on a reductionist version of the NIS-approach that prevents such a “Southern perspective” to fully emerge. This creates problems for actors willing to use NIS more reflexively, and it also affects the effectivity of science, technology and innovation (STI) policies in non-OECD countries. We formulate a research agenda with three suggestions for further engaging NIS both conceptually and practically. Using such analytical perspectives, we argue, might benefit both to scholarly work about NIS, but could also allow for a better articulation with STI regimes in Southern countries. (shrink)

The authors develop an analysis of education. They show how education carries an essentially arbitrary cultural scheme which is actually based on power. More widely, the reproduction of culture through education is shown to play a key part in the reproduction of the whole social system.

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines for local populations. However, the absence of appropriate structures for ethical review represents a barrier for certain countries. Currently there is very little information available on existing structures dedicated to ethics in western and central Africa. This article briefly describes historical milestones in the development of networks dedicated to capacity building in ethical review in these regions and outlines the major conclusions of two (...) workshops on this issue, which were held in September and October 2002 in Libreville, Gabon, and Paris, France. The workshops were the culmination of collaboration between the African Malaria Network Trust (AMANET) and the Pan African Bioethics Initiative (PABIN). They produced an update on ethics organizations with regard to mission, function, activities, members, and contact people, in eight countries within the regions discussed. As a result of the commitment of mandated delegates, a further prominent outcome followed these workshops: the creation of national structures, where none existed before, dedicated to the ethical review of clinical trials. (shrink)

Johnson-Laird's mental models theory claims that reasoning is a semantic process of construction and manipulation of models in working memory of limited capacity. Accordingly, both a deduction and a given interpretation of a premise would be all the harder the higher the number of models they require. The purpose of the present experiment was twofold. First, it aimed to demonstrate that the interpretation of if...then conditional sentences in children (third, sixth, and ninth graders) evolves as a function of the number (...) of models the children can produce. We proposed a theory of conditional reasoning development that hypothesises a developmental trend of three successive levels of interpretations underlain by one, two, and then three models, i.e. conjunctive, biconditional, and conditional respectively. Second, we aimed to show that these different levels correlate with working memory capacities: the higher the working memory span, the higher the number of models underlying the conditional interpretation. These two hypotheses were verified, supporting the mental models theory. The results are compared with the rival theory of mental logic. (shrink)

I examine Adorno's controversial claim that human rationality is inherently mimetic. To do so, I break this claim down into three puzzles and consider each in turn. The first puzzle originates in Adorno's assertion that in the course of human history the mimetic moment of human thought is melted together with the rational moment. So whereas, on his narrative, mimesis has become an intrinsic component of human rationality, it appears that we are oblivious to this state of affair and unable (...) to recognize the workings of mimesis in what we otherwise refer to as rationality. The second puzzle concerns the traditional metaphysical question regarding the possibility of knowledge. Adorno holds that the key to this question lies in the "mimetic moment of knowledge", which he characterizes as the moment of the elective affinity between the knower and the known. The third puzzle concerns his views on how the mimetic moment of thought plays out in our epistemic practices. As he puts it, "consciousness knows of its other as much as it resembles that other," which seems to entail that our very efforts to conceptualize objects somehow rely on imitative processes. I work out what I take to be the basics of Adorno's understanding of mimesis and use them to make sense of each puzzle. I argue that Adorno's insistence on the mimetic component of human rationality isn't meant to promote more mimetic modes of comportment, but a reflexive awareness of the extent to which our rational activities already rely on imitative processes, even those we view as embodying the strongest claims to the contrary. (shrink)

Through a detailed study of Spinoza's concept of 'experience', Moreau shows how Spinoza extends the power of reason to capture the singularity of individuals: their lives, languages, passions and societies.

Le texte qui suit est un entretien réalisé à Grenoble, le 22 octobre 2015, avec François Jullien, professeur à Paris 7, philosophe, helléniste et sinologue, titulaire de la chaire sur l’altérité à la Maison des sciences de l’homme. Il s’entretient avec Claude Fintz, professeur de langue et littérature françaises à l’Université Grenoble Alpes. François Jullien évoque d’abord des questions méthodologiques ; puis il développe sa conception de l’entretien, du métissage culturel, ainsi que sa critique des notions d’entre-deux et d’imaginaire. (...) The text which follows is an interview, realized in Grenoble, 22 October 2015, with François Jullien, professor in Paris 7, philosopher, hellenist and sinologist, holder of the pulpit on the otherness to the the House of the Human Sciences. He speaks with Claude Fintz, professor of French contemporary language and literature in Université Grenoble Alpes. First François Jullien evokes methodological questions; then he develops his conception of the interview, the cultural interbreeding, as well as his criticism of the notions of in-between and imaginary. (shrink)